Vetnuus | Desember 2023 12 « BACK TO CONTENTS Nutraceutical category investigated Nutraceutical compound investigated Author Study type Groups Sample size Study length Outcome measures Conclusions Evidence level (Aragon & Budsberg 2005) Tabel 2 continued Hielm-Björkman et al. (2009) Double-blind, randomised, placebocontrolled study Green-lipped mussel Carprofen Placebo (isotonic sodium-chloride solution) 45 dogs 8 weeks Subjective: veterinary-assessed mobility index and owner-evaluated chronic pain index via VAS Objective: force plate analysis (PVF) Freeze-dried green-lipped mussel is more effective than the placebo in treating chronic pain due to moderate to severe. Although green-lipped mussel was not as effective as carprofen II Soontornvipart et al. (2015) Double-blind, randomised, non-placebo controlled study Green-lipped mussel Omega-3 fatty acids in fish oil 66 dogs 24 weeks Subjective: veterinary assessment, weightbearing scores Objective: serum OA biomarkers (WF6), force plate analysis (PVF), range of motion (ROM) via goniometer Green-lipped mussel administration led to good clinical outcomes. The fish oil did not show any positive effects in the canine OA treatment III Vijarnsorn et al. (2019) Randomised, doubleblinded study Firocoxib Greenlipped mussel Combination of firocoxib and Green-lipped mussel 79 dogs 4 weeks Subjective: veterinary assessment (OAS (orthopaedic assessment score) CMI: CBPI Objective: PVF, serum prostaglandin E2 concentration A combination of both greenlipped mussel and firocoxib is most effective in alleviation of inflammation and improvement of weight bearing ability II Fish oil (Omega-3) Hielm-Björkman et al. (2012) Double-blind, randomised, placebocontrolled study Deep sea fish oil Corn oil (placebo) 77 dogs 16 weeks Subjective: locomotion assessment via VAS, QoL VAS, comparative questionnaire, veterinary assessment, owner assessment of outcome CMI: HCPI Objective: PVF and VI, use of rescue NSAIDs There was no statistically significant benefit in using deep sea fish oil as an analgesic However, owners indicated an improvement in mobility at the end of the study with the HCPI CMI II Mehler et al. (2016) Double-blind, randomised, placebocontrolled, cross-over designed study Triglyceride n-3 oil Placebo oil 78 dogs 84 days Subjective: veterinary assessment using multiple VAS Daily supplementation of a dog’s diet with omega-3 correlates to reduced pain and lameness in OA dogs II
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