December 2023 11 Table 2. Studies investigating nutraceuticals as a treatment for canine osteoarthritis Nutraceutical category investigated Nutraceutical compound investigated Author Study type Groups Sample size Study length Outcome measures Conclusions Evidence level (Aragon & Budsberg 2005) Omega-3-based nutraceuticals Green-lipped mussel (Perna canaliculus) Bierer & Bui (2002) Double-blind, randomised, non-placebo- controlled study Green-lipped mussel powder Green-lipped mussel incorporated into a treat Green-lipped mussel incorporated into a main meal 96 dogs 6 weeks Subjective: veterinary assessment, NRS Total OA scores and scores for joint pain and joint swelling were significantly reduced following 6 weeks of greenlipped mussel supplementation in all three forms III Dobenecker et al. (2002) Double-blind, randomised, placebocontrolled study Chondroitin sulphate Mussel extract Placebo 70 dogs 12 weeks Subjective: owner-reported questionnaire, veterinary assessment None of the tested substances led to a distinct improvement of the recorded symptoms or even to a total recovery in general II Pollard et al. (2006) Double-blind, randomised, placebo controlled study Green-lipped mussel Placebo 81 dogs 56 days Subjective: owner-reported questionnaire, veterinary assessment Green-lipped mussel had a beneficial effect on the clinical signs of dogs presumptively diagnosed with mild-to- moderate DJD II Dear SAVA member Please note that Vethouse will close on Thursday, 21 December 2023 at 12:00 and resume business on 03 January 2024. SAVA wishes all its members and their families a joyous festive season and everything of the best for the year ahead. Kind regards Gert Steyn: Managing Director Geagte SAVV lid Neem asseblief kennis dat Vethuis sal sluit op Donderdag, 21 Desember 2023 om 12:00 en sal heropen op 03 Januarie 2024. Die SAVV wens alle lede en hul families ‘n wonderlike feestyd en alles van die beste vir die jaar wat voorlê. Vriendelike groete Gert Steyn: Besturende Direkteur Leading Article >>> 12
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