Vetnuus | Desember 2023 10 « BACK TO CONTENTS Leading Article Table 1. Studies investigating weight loss as a treatment for canine osteoarthritis Author Study Type Groups Sample Size Study Length Outcome measurements Conclusions Evidence level (Aragon & Budsberg 2005) Impellizeri et al. (2000) Non-blinded prospective clinical trial Weight loss programme 9 19 weeks Subjective: NRS, VAS Dogs lost between 11% and 18% of their bodyweight over 10 to 19 weeks. All measures of lameness were significantly lower at the end of the study compared to baseline III Burkholder & Hulse (2000)† Non-blinded prospective clinical trial Weight loss programme 16 Not given Objective: kinetic gait analysis Significant improvement in objective measurements with weight loss to optimal body condition III Mlacnik et al. (2006) Non-blinded prospective randomised clinical trial Caloric restriction and intensive physical therapy including TENS caloric restriction and home-based physical therapy 29 6 months Subjective: subjective lameness and pain scores (0 to 4) Objective: kinetic gait analysis Mean weight loss after 6 months was 13.6% in group 1 (caloric restriction and intensive physical therapy) and 9.3% in group 2 (caloric restriction and home-based physical therapy). Significant improvement in kinetic gait analysis in both groups at end of study, but more rapid change was evident in dogs receiving intensive physical therapy III Marshall et al. (2010) Non-blinded prospective clinical trial Weight loss programme 14 16 weeks Subjective: NRS, VAS Objective: kinetic gait analysis Dogs lost an average of 8.6% of initial bodyweight. Significant decrease in subjective measures of lameness from weight loss of 6.1% of bodyweight onwards. Significant reduction in objective measurements of lameness from 8.85% onwards III NRS Numerical rating scale, VAS Visual analogue scale, TENS Transcutaneous electrical nerve stimulation
RkJQdWJsaXNoZXIy OTc5MDU=