December 2023 13 Moreau et al. (2013) Double-blind, randomised, placebocontrolled study Veterinary therapeutic diet rich in omega-3 fatty acids (omega-3) from fish origin Regular diet used as control 30 dogs 13 weeks Subjective: veterinary assessment CMI: CSOM Objective: force plate analysis (PVF) High levels of omega-3 from fish origin improved both CSOM and PVF scores II Collagen-based nutraceuticals Collagen Deparle et al. (2005) Double-blind, randomised, placebocontrolled study No undenatured type-II collagen (placebo) Undenatured type-II collagen at 1 mg/day Undenatured type-II collagen at 10 mg/day 15 dogs 90 days followed by a 30-day withdrawal period Subjective: veterinary assessment using VAS and observational questionnaire Objective: biochemical assay (creatinine, blood urea nitrogen, alanine aminotransferase and aspartate aminotransferase) Daily treatment of arthritic dogs with undenatured type-II collagen reduces signs and symptoms associated with OA. The greatest physical improvements were noted after a treatment period of 90 days II Stabile et al. (2019) Blinded, randomised, prospective, controlled study Undenatured type-II collagen (1 tablet/day) Robenacoxib (1 mg/kg/day) 60 dogs 30 days Subjective: veterinary assessment CMI: LOAD questionnaire Objective: radiography The results of this study showed that undenatured type-II collagen and robenacoxib were able to similarly improve mobility of dogs affected by OA Collagen, glucosamine hydrochloride and chondroitin sulphate II Gupta et al. (2012) Double-blind, randomised, placebocontrolled study Placebo 10 mg active undenatured type-II collagen 2000 mg glucosamine hydrochloride and 1600 mg chondroitin sulphate 10 mg active undenatured type-II collagen, 2000 mg glucosamine hydrochloride and 1600 mg chondroitin sulphate 7 to 10 dogs per group 150 days Subjective: veterinary assessment by multiple VAS and visual gait analysis Objective: force plate analysis (PVF and VI) and biochemical assay (creatinine, blood urea nitrogen, alanine aminotransferase and aspartate aminotransferase) Dogs treated daily with undenatured type-II collagen (10 mg) showed a marked reduction in OA pain with maximum improvement seen on day 150. Efficacy of undenatured type-II collagen is significantly greater than glucosamine hydrochloride and chondroitin sulphate II Leading Article 24-Hour Toll-Free Helpline: 0800 21 21 21 Nutraceutical category investigated Nutraceutical compound investigated Author Study type Groups Sample size Study length Outcome measures Conclusions Evidence level (Aragon & Budsberg 2005) Tabel 2 continued
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