December 2023 15 Scott et al. (2017) Double-blind, randomised placebocontrolled study Glucosamine hydrochloride and chondroitin sulphate Placebo 60 dogs 97 days Subjective: veterinary assessment CMI: canine brief pain inventory (CBPI) Treatment with oral glucosamine hydrochloride and chondroitin sulphate for a 90-day treatment period when compared to placebo treatment did not result in a significant increase in activity counts in dogs with clinical OA II Others Curcumoids Innes et al. (2003) Double-blind randomised placebocontrolled parallel group clinical study P54FP Placebo 61 dogs 8 weeks Subjective: veterinary assessment, ownerreported assessment Objective: force plate analysis (PVF and VI) Results showed statistically significant treatment effect in favour of P54FP (P>0.05), but the owners’ assessment just failed to reach statistical significance II Elk velvet antler Moreau et al. (2004) Double-blind, randomised placebocontrolled study Quality elk velvet antler for 60 days (n=25 dogs) Placebo for 30 days and then quality elk velvet antler for 30 days (n=13 dogs) 38 dogs 60 days Subjective: veterinary assessment, owner interpretation Objective: Force plate analysis (GRF), radiography Performances in daily life activities, and vitality were significantly improved on quality elk velvet antler, exceeding those observed when placebo was administered. Thirteen dogs did not show significant improvement II Vitamin E Rhouma et al. (2013) Double-blind, randomised placebocontrolled study Placebo (n=8) Vitamin E group receiving 400 IU/animal per day 15 dogs 55 days Subjective: VAS and NRS Objective: electrodermal activity (EDA), structural assessment of stifle joints at day 56 Supplement with a high dose of vitamin E showed a reduction in inflammation joint markers and histological expression, as well as a trend to improving signs of pain II Nutraceutical category investigated Nutraceutical compound investigated Author Study type Groups Sample size Study length Outcome measures Conclusions Evidence level (Aragon & Budsberg 2005) Tabel 2 continued Leading Article >>> 16
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