VN August 2022

Vetnews | Augustus 2022 11 After 12 weeks of therapy, Raven’s body weight had more than doubled (from2.05kgto4.3kg),andhisBCSwas5/9.Hisocularexamwasnormal,with the keratitis fully healed. He was fully mobile and showed no neurological signs; all haematological and biochemical parameters had normalised. He was fully continent. Fourteenmonths after treatment ended, Raven is still doingwell. FIP is no longer the undefeatable enemy of every cat-owner. Although treatment is not easy and not inexpensive, Squirrel and Raven are only two of many examples of cats that have survived this deadly disease. Hopefully, more possibilities for treatment and prevention will emerge with the world more focussed than ever on anti-viral medications, and with FIP being an interestingmodel for COVID. v Addie, D., Silveira, C., Aston, C., Brauckmann, P., Covell-Ritchie, J., Felstead, C., Fosbery, M., Gibbins, C.,Macaulay,K.,McMurrough,J.,Pattison,E.,&Robertson,E.(2022).Alpha-1AcidGlycoprotein ReductionDifferentiatedRecoveryfromRemissioninaSmallCohortofCatsTreatedforFeline InfectiousPeritonitis. Viruses , 14 (4),744 .https://doi.org/10.3390/V14040744 Barker, E. N., Stranieri, A., Helps, C. R., Porter, E. L., Davidson, A. D., Day, M. J., Knowles, T., Kipar, A., & Tasker, S. (2017). Limitations of using feline coronavirus spike protein gene mutations to diagnose feline infectious peritonitis. Veterinary Research , 48 (1). https://doi.org/10.1186/s13567-017-0467-9 Felten, S., & Hartmann, K. (2019). Diagnosis of feline infectious peritonitis: A review of the current literature. Viruses , 11 (11). https://doi.org/10.3390/V11111068 Jones, S., Novicoff, W., Nadeau, J., & Evans, S. (2021). Unlicensed gs-441524-like anti- viral therapy can be effective for at-home treatment of feline infectious peritonitis. Animals , 11 (8). https://doi.org/10.3390/ani11082257 Kennedy, M. A. (2020). Feline Infectious Peritonitis: Update on Pathogenesis, Diagnostics, and Treatment. In Veterinary Clinics of North America - Small Animal Practice (Vol. 50, Issue 5, pp. 1001–1011). W.B. Saunders. https://doi.org/10.1016/j. cvsm.2020.05.002 Meli, M. L., Burr, P., Decaro, N., Graham, E., Jarrett, O., Lutz, H., McDonald, M., & Addie, D. D. (2013). Samples with high virus load cause a trend toward lower signal in feline coronavirus antibody tests. Journal of Feline Medicine and Surgery , 15 (4), 295–299. https://doi.org/10.1177/1098612X12467995 Murphy, B. G., Perron, M., Murakami, E., Bauer, K., Park, Y., Eckstrand, C., Liepnieks, M., & Pedersen, N. C. (2018). The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Veterinary Microbiology , 219 , 226–233. https://doi.org/10.1016/j. vetmic.2018.04.026 Pedersen DVM, N. C. (n.d.). A review of feline infectious peritonitis virus infection: 1963e2008 . https://doi.org/10.1016/j.jfms.2008.09.008 Pedersen, N. C. (2014). An update on feline infectious peritonitis: Virology and immunopathogenesis. In Veterinary Journal (Vol. 201, Issue 2, pp. 123–132). Bailliere Tindall Ltd. https://doi.org/10.1016/j.tvjl.2014.04.017 Pedersen, N. C., Eckstrand, C., Liu, H., Leutenegger, C., & Murphy, B. (2015). Levels of feline infectious peritonitis virus in blood, effusions, and various tissues and the role of lymphopenia in disease outcome following experimental infection. Veterinary Microbiology , 175 (2–4), 157–166. https://doi.org/10.1016/j.vetmic.2014.10.025 Pedersen, N. C., Perron, M., Bannasch, M., Montgomery, E., Murakami, E., Liepnieks, M., & Liu, H. (2019). Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis. Journal of Feline Medicine and Surgery , 21 (4), 271–281. https://doi.rg/10.1177/1098612X19825701 Pederson, N. (n.d.). Summary of GS-441524 treatment for FIP . UC Davies. Retrieved July 19, 2022, from https://ccah.vetmed.ucdavis.edu/sites/g/files/dgvnsk4586/files/ inline-files/Summary%20of%20GS-441524%20treatment%20v5.pdf Pederson, N., & Jacque, N. (2021, November). Alternative treatments for cats with FIP and natural or acquired resistence to GS-441524 . https://ccah.vetmed.ucdavis.edu/ sites/g/files/dgvnsk4586/files/inline-files/Approaches-to-drug-resistance-in-cats- treated-with-GS-441524-for-FIP-v3.pdf Tekes, G., & Thiel, H.-J. (n.d.). Feline Coronaviruses: Pathogenesis of Feline Infectious Peritonitis . https://doi.org/10.1016/bs.aivir.2016.08.002 Leading Article Glucose 9.6mmol/l (4.11-8.84) Creatinine 43umol/l (71-212) Urea 7.4mmol/l (5.7-12.9) TP 95g/l (57-89) Albumin 25g/l (22-40) Globulin 70g/l (28-51) Alb/Glob 0.4 ALT 212U/L (12-130) ALKP 117U/L (14-111) RCC 3.4 x 10 12 /l (5.3-10.60) Ht 16% (29.7-44.5) Retic 23.2K/ul (3.0-50.0) Neutrophils 14.25 x 10 9 /l (2.5-12.5) Lymphocytes 0.8 x x 10 9 /l (0.40-6.80) Monocytes 1.5 x x 10 9 /l (0.15-1.7)